Trainee Journal Club Volunteer Form
Are you interested in presenting a Thyroid paper for the ATA’s new trainee and early career journal club? We have identified three high impact papers published in the Thyroid journal and are looking for individuals that would be willing to help us present the papers during a future Career Connections Meetup. We will be pairing 2 trainee presenters and an expert ATA member who will serve as a moderator. The moderator will provide insight into how this paper fits into the current landscape and field, either clinically or scientifically.
If you are a trainee or early career professional and interested in presenting one of the papers listed below please complete this form.
Questions? Email trainees@thyroid.org
Papers:
Exogenous 3-Iodothyronamine Rescues the Entorhinal Cortex from beta-Amyloid Toxicity:
A novel form of thyroid hormone (TH) signaling is represented by 3-iodothyronamine, an endogenous TH derivative that interacts with specific molecular targets, including the trace amine-associated receptor 1 (T1AM), and induces pro-learning and anti-amnestic effects in mice. This represents a novel signaling pathway linked to memory and loss of memory. Dysregulation of TH signaling has long been hypothesized to play a role in Alzheimer’s disease. In this study, the authors explored the neuroprotective role of T1AM in beta amyloid (Aβ)-induced synaptic and behavioral impairment, focusing on a specific area within the brain that is affected early in Alzheimer’s Disease pathology and progression.
https://www.liebertpub.com/doi/10.1089/thy.2019.0255
Dissecting Anaplastic Thyroid Carcinoma: A Comprehensive Clinical, Histologic, Immunophenotypic, and Molecular Study of 360 Cases:
This study the largest study to date to investigate and link the clinical, genetic and histological characteristics if Anaplastic thyroid cancer. The study is retrospective evaluating patients from two tertiary centers.
https://www.liebertpub.com/doi/10.1089/thy.2020.0086
Comprehensive Immune Profiling of Medullary Thyroid Cancer:
This study is the first one to comprehensively investigate and define the immune milieu, immune-suppressive molecules and tumor antigens in MTC patients. 46 patients were evaluated in the study, finding robust infiltration of CD8+ T cells and macrophages in these tumors and metastatic lesions. This study identifies and describes how immune modulatory therapies may be a novel approach for treatment of MTC including potential for developing adoptive T cell therapies to treat MTC.
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