CLINICAL THYROIDOLOGY FOR PATIENTS
A publication of the American Thyroid Association

Summaries for Patients from Clinical Thyroidology (from recent articles in Clinical Thyroidology)
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THYROID HORMONE THERAPY
Taking levothyroxine with breakfast may be fine for many patients

BACKGROUND
Levothyroxine is the most common therapy for the treatment of hypothyroidism as it is the same as the major thyroid hormone produced by the thyroid gland. The absorption of levothyroxine in the gut is decreased when taking the hormone at the same time as calcium, iron and some foods and other drugs. Because of this, patients are usually instructed to take levothyroxine on an empty stomach 30-60 minutes before food intake to avoid erratic absorption of the hormone. For many patients, this means first thing in the morning before breakfast. This is often difficult for many patients, especially those on multiple medications. This study was performed to see if patients can take their levothyroxine with food in the morning and not have to wait 30-60 minutes.

THE FULL ARTICLE TITLE:
Perez CL et al. Serum thyrotropin levels following levothyroxine administration at breakfast. Thyroid 2013;23:779-84. Epub June 21, 2013.

SUMMARY OF THE STUDY
This study was performed in Brazil and included 45 patients who had a diagnosis of hypothyroidism and a normal TSH level on levothyroxine therapy. For 90 days patients were assigned either to take the levothyroxine 30-60 minutes be- fore a meal or during the morning meal. Then after 90 days, they switched to the other regimen. TSH levels were assessed at baseline, 45, 90, 135 and 180 days after the start of the study. Patients reported all of their food intake at breakfast. As expected, 90% of the patient population was women.

The average TSH at the start of the study was 1.7. The TSH level was higher when levothyroxine was taken during breakfast (TSH 2.9) as compared with group who waited 30-60 minutes before taking levothyroxine (TSH 1.9). Patient preference was assessed at the end of the study and 41% preferred taking levothyroxine and waiting, 33% preferred taking the levothyroxine with breakfast and 26% indicated no preference.

WHAT ARE THE IMPLICATIONS OF THIS STUDY?
This study shows that the absorption of levothyroxine is indeed decreased when taking the hormone with breakfast. Despite an increase in TSH while taking the hormone with breakfast, the TSH remained within the normal range. Thus, while taking levothyroxine with breakfast could be an alternative regimen for patients who have difficulties taking the hormone on an empty stomach, this regimen is more likely to cause variability in the TSH level. It is still advised that patients with a history of thyroid cancer, those who are pregnant or those who are very sensitive to changes in their TSH level need to likely wait 30–60 minutes prior to taking there levothyroxine.

—Heather Hofflich, DO

ATA THYROID BROCHURE LINKS

Hypothyroidism: http://www.thyroid.org/what-is-hypothyroidism

Thyroid Hormone Treatment: http://www.thyroid.org/thyroid-hormone-treatment

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