BACKGROUND
Thyroid hormones are critical for the growth and development of babies during pregnancy. During the first trimester of pregnancy, the mother supplies thyroid hormones. However, starting in the second trimester, the developing baby is able to produce his/her own thyroid hormone. T4 is the major form of thyroid hormone released by the thyroid gland and T3 is the most active form of thyroid hormone. Both are controlled by thyroid stimulating hormone (TSH). Chemicals that disrupt endocrine glands (endocrine disruptors) are being studied. Organic compounds, chemicals such as cadmium and cigarette smoking may affect thyroid regulation. Air pollution is a mixture of several particles, including metals, nitrate and organic materials, which have been shown to affect endocrine glands. Exposure to air pollution has also been associated with an increased risk for low birth weight and preterm birth. However, the role of air pollution on the baby’s thyroid during pregnancy is not known. This study was done to determine whether exposure to air pollution during late pregnancy affects the mother’s and/or the baby’s thyroid function and birth weight.
THE FULL ARTICLE TITLE:
Janssen BG et al Fetal thyroid function, birth weight, and in utero exposure to fine particle air pollution: a birth cohort study. Environ Health Perspect. September 13, 2016
SUMMARY OF THE STUDY
The authors studied 640 mother–child pairs from the East Limburg Hospital in Genk, Belgium, between February 2010 and June 2014. Mother-children pairs were part of the ENVIRONAGE birth cohort study. They obtained data from small particles in the air, with a diameter equal or less to 2.5 μm, based on the mother’s home address using a system that permits correlation with space and time from satellite images. Using this system, they were able to obtain daily air small particle values using data from the Belgian network that studies air-quality. The outcomes were obtained for the third trimester of pregnancy and the average exposure value was used after correction for environmental factors such as temperature and humidity. Data on subject characteristics was obtained through questionnaires. They also reviewed other factors associated with pregnancies, by reviewing the medical files of the hospital. Umbilical cord and blood samples from the mother were collected at the time of delivery or up to 1 day after delivery. They had data for 499 newborns and 431 mothers.